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The researchers identified the PI3K/AKT signaling pathway as a key mechanism mediating Dihexa's cognitive benefits, expanding the mechanistic understanding beyond the original HGF/c-Met focus

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The nasal spray form gained popularity for its convenience, though its efficacy is modest compared to bisphosphonates and the newer anabolic agents

2025;213(5S)

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Notably, treatment with the PKC inhibitor eliminated the difference in adipogenic capacity between control and GPR146-deficient cells, suggesting that impaired PKC signaling underlies the differentiation defect caused by GPR146 loss in both human and mouse preadipocytes (Fig