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Waiting two years for retatrutide while metabolic dysfunction continues isn't a neutral decision the costs of delay are real

GLP-1 medications are FDA-approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27-29.9) with at least one weight-related comorbidity

A retrospective analysis of the DURATION trials found that overall, greater weight loss was associated with gastrointestinal adverse events with exenatide once weekly and exenatide twice daily

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Although early, these findings highlight how therapies developed for cardiometabolic disease may intersect with hallmarks such as telomere attrition

However, we know both of these diseases are related to inflammatory markers and the presenters did have data on high-sensitivity C-reactive protein or hsCRP