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00:14:13 Steve Small: Yeah, and despite this, the labeling on Wegovy and other GLP-1s approved for weight loss do mention suicidal behavior as a warning

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This requires a deep understanding of nutrient absorption and cleverly engineering the medicine to hitch a ride on these pathways

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Treatment requires gradual dose titration from 2.5mg to maintenance doses (5mg15mg) at minimum 4-week intervals to improve tolerability

These changes are temporary and reflect the bodys hormonal recalibration as fat tissue (a significant source of estrogen production) decreases