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Diabetes Obes Metab 2020
Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study
These observations are corroborated at the molecular level, with dysregulation in the expression of pro-proliferative proteins (e.g., cyclin D1) and tight junction proteins (e.g., zonula occludens-1, occludin, and claudin 1, 4, and 8) (Birder, 2019)
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adults affected, leading to annual healthcare costs of $173 billion
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