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Glutathione (GSH) is an antioxidant that is present in plants, animals, and fungi, and found in nearly every cell of the human brain and body

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The 1st glutathione-interaction site should be frequently (although transiently) occupied by GSH at millimolar concentrations, whereas diverse non-glutathione disulfide substrates are far less abundant in vivo and should encounter the active site less frequently

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