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Mental health changes: Semaglutide may cause sudden changes in mood, behavior, or emotional state

But awareness alone will not improve outcomes

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As a result, treatment extends beyond weight loss alone to address the medical, emotional, and lifestyle factors that influence long-term outcomes

An estimate of the potential benefit of quadruple therapy suggests an advantage for the kidney composite outcome of doubling of serum creatinine, kidney failure, or death from kidney failure (HR 0.42, 95% CI 0.31 to 0.56) and improved cardiovascular survival benefits [80]