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However, although an area may appear pigmented, the discoloration may not be related to actual pigment, but rather to the deposition or accumulation of organic or inorganic substances, including various metals and drug metabolites

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These symptoms may indicate liver dysfunction requiring prompt medical evaluation

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Vomiting follows nausea in prevalence, affecting roughly 510% of people, while diarrhea and constipation each occur in 1530% of patients during the titration phase