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The combination leads to endothelial dysfunction, cholesterol deposition, inflammation, and finally, calcification.[ref] Oxidized phospholipids are primarily polyunsaturated fatty acids that are oxidized due to ROS, infections, or apoptosis

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Although a full understanding of the mechanism of OCTN2 transport will require additional structural characterisation, particularly of outward-facing conformations, the data presented here provides a strong foundation for our proposed mechanism