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For participants receiving 40 mg daily of oral semaglutide, three different dose-titration protocols were used where patients were titrated up to the full 40 mg dose in 6 weeks (fast dose escalation), 12 weeks (standard dose escalation), or 24 weeks (slow dose escalation)
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The phase 2 trial used a structured escalation from 1 mg through 4 mg, 8 mg, and 12 mg over multiple months [1]
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Medications like GLP-1s are designed to help reset this metabolic thermostat. While adding a drug like phentermine might seem like a shortcut, the real goal is to create a lifestyle where you no longer need to rely on stimulants to control your appetite
