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Another rare but serious risk is pancreatitis, which presents as severe abdominal pain, sometimes radiating to the back, and may be accompanied by nausea and vomiting
Slowing your titration schedule may extend your adjustment period, but it typically results in fewer missed doses and better long-term adherence
It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
Other possible risks include dizziness, fatigue, headache, stomach discomfort, bloating, indigestion, gas pains, and burping
It is FDA-approved as Ozempic (2017), Wegovy (2021), and Rybelsus (2019, oral formulation), and serves as the reference compound for the broader class of long-acting GLP-1 receptor agonists
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