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This happens because when you stop the treatment, the effects of medication, such as reduced appetite and slower digestion, gradually fade and lead to an increase in hunger cravings and higher calorie intake
On the other hand, low portal insulin levels (e.g., during prolonged fasting) reduce hepatic GHR expression, thereby reducing IGF-1 levels and increasing GH concentrations by the lack of IGF-1 feedback on pituitary GH secretion (Fig
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doi:10.1038/s41467-025-58680-y Carvas AO, Leuthardt A, Kulka P, et al
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