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By eliminating senescent cells in preclinical systems, FOXO4-DRI indirectly reduces the source of SASP factors

Oxeiptosis is a caspase-independent cell death that is triggered by oxidative stress and acts in the elimination of pathogens

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Unprotected glutathione decreased levels of the active form by 40 points

Unlike GLP-1, GIP can promote glucagon secretion in normal and hypoglycemic states, and inhibit it in hyperglycemia, thus acting as a bifunctional hormone to maintain blood glucose homeostasis

Tesofensine lowers body weight mainly by reducing appetite, increasing satiety, and enhancing energy expenditure, making it a promising candidate for the pharmacological treatment of obesity 1-4 .