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292 In HCC, intracellular lactate triggers histone H3K18 lactylation, promoting HECTD2 transcription

Pineal peptides take the opposite approach

doi: 10.1038/s41586-020-2456-9 231 Robledinos-AntnN.Fernndez-GinsR.MandaG.CuadradoA

Excess glutamate binds to the cell surface glutamate receptors NMDARs (N-methyl-D-aspartic acid receptors), leading to a toxic effect of calcium influx and ultimately causing RGC death (74)