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Upper arms work well though they prove more difficult for self-administration without assistance

The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation

Other metabolic side effects could be hypokalemia (low potassium levels in the body), extreme thirst, rapid weight gain, frequent urination and/or unexplained bleeding or bruising

Peptides that support neurological function may help address these dimensions of the disease

The two peptides are clinically synergistic. No controlled combination trial was identified