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Krantz S, et al

This principle underlies the development of Retatrutide and other next generation obesity medications

Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis

Takeaway: For HFpEF patients with obesity + T2D, GLP-1s and dual agonists are emerging not only as metabolic therapies but as cardiovascular disease-modifying agents

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Human trials show major body-weight reductions, with some evidence suggesting results may approach the 30% range