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Why the Caution

and (2) individuals meeting the same initial criteria with documented weight measurements at 12 months, who demonstrated an average body weight reduction of 15.28% as of April 2025

These diabetes-specific results mirror the pattern seen with CagriSema in REDEFINE 2, though direct comparison requires caution because the trial populations and designs differed

doi:10.1186/s12958-020-00591-2

Evidence-based approaches include: Cognitive behavioural therapy (CBT) and stress management techniques Regular physical activity and adequate sleep hygiene Mindfulness-based stress reduction programmes Addressing underlying anxiety or depression with appropriate psychological or pharmacological interventions Patients with adrenal insufficiency require lifelong glucocorticoid replacement therapy, typically with hydrocortisone (1525mg daily in divided doses) to mimic physiological cortisol secretion patterns

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