Increased expression of the FMO3 gene could be a culprit in atherosclerosis and CVD.8 FMO3 may have adverse effects on blood lipids and glucose independently of TMAO formation, although more research is needed.15 Also, in the liver, trimethyllysine (TML), a modified amino acid, can be converted to GBB and then to carnitine and potentially to TMA and TMAO
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After 40 weeks, 78% to 85% of adults taking Mounjaro achieved an HbA1c below 7%, compared with 23% of adults taking a placebo
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