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The higher sensitivity of MDA-T32 and MDA-T68 cells to RSL3 treatment may be due to the fact that RSL3 was originally selected from the chemical screen that showed synthetic lethality against RAS mutation and active TERT expressing cells 26

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Although PIONEER 6 only showed an insignificant reduction of MACE, subcategory analysis demonstrated significant improvement in all-cause mortality [1.4% vs