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HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]
The sensitivity for detection is typically less than 1 pmol/L
Although bariatric surgery led to more weight loss, GLP-1 RAs were associated with better outcomes, suggesting benefits may extend beyond just weight reduction
The reason for this reaction is not fully known at this time, but it has led licensed healthcare professionals to avoid prescribing these drugs to those with a health history of pancreatitis
Access is still an issue for these effective medications. Clare Thompson, MD, a general practitioner who leads weight management services at the Cadogan Clinic in London, agrees
Ipamorelin is a selective growth hormone secretagogue (GHS) that binds to the ghrelin (GHS-R1a) receptor
