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This is particularly true with obesity management drugs

Pfeiffer CC, Braverman ER

Collagen is the most abundant protein in the human body, forming the structural framework of: Skin, hair, and nails Joints, cartilage, and connective tissue Tendons, ligaments, and bones The intestinal lining and gut barrier Natural collagen production declines by ~1% per year from your late 20s, and drops faster with: Calorie restriction Rapid weight loss Hormonal changes (including menopause) (GLP-1 users often experience all three.) Because GLP-1 medications significantly reduce appetite, many people unintentionally eat less protein overall, which can reduce the availability of glycine, proline, and hydroxyproline the amino acids required for collagen synthesis

The effect of GLP-1R agonists liraglutide and exendin-4 was examined in vitro on LOVO, CA-77, MCF-7, MDA-MB-231, KPL-1, MB-468, 4TI, BT483, ZR751, LNCap, PC3, ALVA-41, DU145, LNCap, PANC-1, MiaPaCa-2, PANC, CT26, SKOV3, OVCAR3, OVCAR4, A2780, and ES-2 cell lines that are expressed in several cancers including colorectal, pancreatic, thyroid, breast, prostate, ovarian, and colon (Table 1)

For example, if the initial benefits wane, the dosage or frequency of injections may need to be adjusted

Indeed, cyclers warned side effect issues with the oral candidate (CT-996) could limit its competitiveness ( [60] )