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(for users who already tolerated Semaglutide/Tirzepatide)

A process using laboratory-scale 3 L bioreactors initially controlled at 37C during infection and 20 mL column GSH affinity chromatography columns was established previously, where the empty capsids present in cell culture harvests did not bind to the GSH ligand, and excellent full capsid purity was obtained in the GSH elution ( Prior to the GSH chromatography studies, the cell culture temperature setpoint during infection was studied to maximize the infectious titer

[1] [2] Vomiting occurs in approximately 5-9% of patients taking semaglutide for type 2 diabetes and 20-25% of those using higher doses for weight management

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EELS and EFTEM Both electron energy loss spectroscopy (EELS) and energy-filtered TEM (EFTEM) were performed with an in-column Omega filter JEOL JEM-3200EF TEM operating at 300 kV with a LaB6 electron source