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When you eat less, your body has fewer calories to burn for energy, which can lead to fatigue

JACC Heart Fail 4:559566 Savarese G, Schrage B, Cosentino F, Lund LH, Rosano GMC, Seferovic P, Butler J (2020) Non-insulin antihyperglycaemic drugs and heart failure: an overview of current evidence from randomized controlled trials

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Cureus 16(8): e67232

Research has shown that long-term use of certain drugs can interfere with absorption pathways

However, the comparison of NNT across various drug classes must be nuanced given the NNT values are specific to individual trial design, study population baseline characteristics, and the time of outcome measurement