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Beyond this period, degradation is likely to occur, and repeated freezethaw cycles must be avoided at all costs, as they can quickly destroy the peptides structural integrity
STEP UP: higher dose exploration The STEP UP trial investigated a higher dose of 7.2 mg weekly, three times the standard 2.4 mg dose
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Population pharmacokinetic analyses haven't found big changes in half-life across different BMI ranges the half-life stays roughly around 5 days across studied populations, with exposure broadly similar in people with type 2 diabetes and those with obesity
Concentration differences from compounding pharmacies Compounding pharmacies may use concentrations that differ from the standard research-grade options
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