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The functions of amylin are complementary to insulin and to GLP-1 : Slows gastric emptying , similarly to GLP-1, but more strongly Suppresses glucagon , helps control postprandial glycemia Induces satiety , via the area postrema in the brainstem Regulates weight balance , long-term effect In type 2 diabetes amylin secretion deteriorates in parallel with insulin secretion , as the disease progresses, the -cells lose the ability to produce both hormones at once
The clinical question to ask either platform: which delivery format and dose ladder fits your tolerability profile and genetics, not just your needle preference
Tirzepatide: Also administered via subcutaneous injection, with specific dosing regimens under investigation
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Two major drug classesSGLT2 inhibitors and GLP1 receptor agonistsare leading this paradigm change
PMID: 34360532
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