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Early and later reviews of DSIP describe a peptide with intriguing associations to sleep but no firmly established clinical effect, and one review openly calls it a still unresolved riddle (a review describing DSIP as a still unresolved riddle)
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Additionally, the E6 facilitates the nuclear translocation of -catenin and induces the expression of Wnt signaling downstream target genes like cyclin D1 and c-MYC, leading to cell growth and proliferation [96]
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