The authors thank Lene Wither Takla (Novo Nordisk A/S, Global Drug Discovery, Denmark) for expert technical assistance with conducting the animal studies, Heidi Solvang Nielsen (Novo Nordisk A/S, Global Drug Discovery, Denmark) for dissection of the hippocampus for RNA-seq and histology, as well as Esther Bloem and Susanne Jrgensen for assistance with protein assays (Novo Nordisk A/S, Global Research Technologies, Denmark)
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
Those using GLP-1 medications solely for weight management (without diabetes) are not at risk for diabetic retinopathy progression, though they should report any visual symptoms promptly given the ongoing investigation of rare non-retinopathy eye events
Not because the peptide is underdosed, but because the biological substrate it depends on isn't optimized
To avoid or mitigate such problems, anyone starting semaglutide should begin on a lower dose and slowly work up to 2.4 mg
Me: "How long does the nausea last?" Her: "Lol...week 3?" That answer stuck with me