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Benoist CC, Wright JW, Zhu M, Appleyard SM, Wayman GA, Harding JW

Further randomized clinical trials are needed to evaluate these preliminary findings and to determine the specific ways in which GLP-1s control cancer progression.

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Retatrutide adopts a single continuous helix that penetrates the core of the receptor transmembrane domain (TMD) via its N-terminal segment (residues 113), while its C-terminal segment (residues 1430) interacts with the N-terminal -helix of the ECD, the extracellular tip of TM1 and ECL1 (Fig