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Metabolic levels associated with MTX resistance In addition to the association between metabolic fold change and MTX resistance, we searched for correlations between metabolic concentration and resistance to MTX (expressed as IC50) at 48 and 96 hours in either the presence or absence of the drug ( Table 1 )

Systemic glutathione depletion, combined with elevated ROS, damages the endothelial lining of the blood vessels

In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion

M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload