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In contrast, another study found that late stage of differentiation exposure at 300 nmol/l led to upregulation of lipolytic adipose triglyceride lipase (ATGL), aligning with the known lipolytic effects of GLP-1-RAs in human adipocytes

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They are grounded in endogenous biology, often supported by convergent evidence across species and experimental modalities, and frequently act at integrative nodes that coordinate multiple physiological processes