Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone
In neuronal senescence model studies, the active ingredient of the product can cross the blood-brain barrier (and act directly on neurons in vitro), increase NAD+ levels in nerve cells, protect mitochondrial function, reduce neuronal apoptosis, and promote the synthesis and release of neurotransmitters (such as dopamine and acetylcholine), thereby improving signal transduction in nerve cells
Key areas of research: NNMT Research Metabolic Research Body Composition Research Adipose Tissue Research Energy Expenditure Research Cellular Metabolism Research Glucose Regulation Research Obesity Research Methylation Pathway Research Cellular Energy Research References NNMT Regulates Cellular Metabolism: A Potential Therapeutic Target Discovery of 5-Amino-1MQ as a Potent NNMT Inhibitor The Role of NNMT in Obesity and Metabolic Regulation References are provided for research context only and do not constitute medical claims
Ohno, Y., Nara, A., Nakamichi, S
Vitamin B12 is a water-soluble vitamin
Hepatology 73 , 625643 (2021)