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Journal of Clinical Investigation

doi:10.1002/dmrr.70163 9

Collaboration between primary care providers, endocrinologists, and orthopedic or rheumatology specialists ensures comprehensive care addressing both metabolic health and joint function

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Currently, several countries such as Canada, Australia, and some Asian countries have issued warnings about the quality of counterfeit drugs on the market

The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function