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By contrast, GLP-1 medications such as Ozempic, Wegovy, Mounjaro, and Zepbound are already being used by millions of Americans, making them an especially appealing area for future prevention research

To assess the associations of semaglutide with recurrent AUD diagnosis (recurrent medical encounters for AUD diagnosis), the study population included 4254 patients who had active medical encounters for the diagnosis of obesity in 6/202112/2022, were for the first time (new-user design) prescribed semaglutide or non-GLP-1RA anti-obesity medications during 6/202112/2022 (index event), had a diagnosis of AUD on or before the index event and had a diagnosis of at least one of obesity-associated comorbidities on or before the index event

People with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) or with a personal or family history of medullary thyroid carcinoma (MTC) should not use semaglutide

611619, doi:10.1080/14656566.2024.2343092, PMID 38629387

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At present, it is not known whether the enhanced toxicity evident in rat and human liver slices when compared to mouse liver slices can be attributed to a species difference in formation of reactive intermediates, detoxification of these metabolites and/or to other considerations