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No, increasing the dose too quickly can cause severe side effects like nausea and vomiting
Pharmacopeial Convention
Abbreviations ADIPOQ: Adiponectin ADRP: Adipose differentiation-related protein ADSC: Adipose tissue derived Stem Cells ALP: Alkaline phosphatase AMPK: AMP-activated protein kinase ANG-1: Angiopoietin-1 APN: Adiponectin APOM: Apolipoprotein M AP2: Activator Protein 2 ATGL: Adipose triglyceride lipase BAX: Bcl-2-associated X protein BCL-2: B-cell lymphoma 2 BMP2: Bone morphogenetic protein 2 BMSC: Bone marrow mesenchymal stem cell C/EBP: CCAAT/enhancer-binding protein alpha cAMP: Cyclic adenosine monophosphate CAV1: Caveolin-1 CCK-8: Cell Counting Kit-8 CDK: Cyclin-dependent kinase CERSS: Ceramide synthase 5 COL1: Collagen type I COL10A1: Collagen type X alpha 1 chain COL1A1: Collagen type I alpha 1 chain COL2: Collagen type II COLI: Collagen-1 DEGS1: Delta (4) -desaturase, sphingolipid 1 DKK-1: Dickkopf-1 DLK1: Delta-like 1 homolog DMEM: Dulbeccos Modified Eagle Medium DTZ: Dithizone EAT: Epicardial adipose tissue EdU: 5-ethynyl-2-deoxyuridin EGF: Endothelial-growth factor EPC: Endothelial progenitor cells ERK: Extracellular signal-regulated kinase Ex-4: Exendin-4 FABP4: Fatty acid-binding protein 4 FASN: Fatty acid synthase FBS: Fetal bovine serum FOXO1: Forkhead box protein O1 GIP: Gastric inhibitory polypeptide GIP-R: Gastric inhibitory peptide receptor GIP-RA: Gastric inhibitory polypeptide receptor agonist GLP-1: Glucagon-like peptide-1 GLP-1-R: Glucagon-like peptide-1 receptor GLP-1-RA: Glucagon-like-peptide-1 receptor agonist GLUT1: Glucose transporter type 1 GLUT2: Glucose transporter type 2 GLUT4: Glucose transporter type 4 GSK-3: Glycogensynthase-kinase 3 beta hASC: human adipose-derived stem cells hDPSC: Human dental pulp stem cells HGF: Hepatocyte-growth factor hMSC: Human mesenchymal stem cells HMSC-E4: HMSC that overexpress Ex-4 HSL: Hormone-sensitive lipase IBMX: 3-Isobutyl-1-methylxanthine IGFBP2: Insulin-like growth factor-binding protein 2 IL-10: Interleukin 10 IL1B: Interleukin 1 beta IL6: Interleukin 6 INGA-PP: Islet Neogenesis-associated protein pentadecapeptide INSR: Insulin receptor IPC: Insulin-producing cells ISL-1: ISL LIM homeobox 1 JNK: c-Jun N-terminal kinase KGF: Keratinocyte growth factor LD: Lipid droplets LiCl: Lithium chloride LINC000968: Long intergenic non-coding RNA 968 LPL: Lipoprotein lipase LPS: Lipopolysaccharides MAFA: V-maf musculoaponeurotic fibrosarcoma oncogene homolog A MAPK: Mitogen-activated protein kinase MCP1: Monocyte chemoattractant protein-1 miRNA: MicroRNA MMP9: Matrix-Metalloproteinase 9 MTS: 3-(4,5-Dimethylthiazol-2-yl) -5-(3-carboxymethoxyphenyl) -2-(4-sulfophenyl) -2 H-tetrazolium MTT: 3-(4,5-di methylthiazol-2-yl) -2,5-diphenyltetrazolium bromide NFkB: Nuclear factor kappa-light-chain-enhancer of activated B cells NGN3: Neurogenin-3 Nkx2.2: NK2 homeobox 2 OCN: Osteocalcin OSX: Osterix (SP7 transcription factor) PAX4: Paired box gene 4 PCNA: Proliferating cell nuclear antigen PDLSC: Periodontal ligament stem cells PDX-1: Pancreatic and duodenal homeobox 1 PGC1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PLIN1: Perilipin 1 PPAR: Peroxisome proliferator-activated receptor gamma pref-1: Pre-adipocyte factor-1 QUIN: Quality Assessment Tool For In Vitro Studies RAGE: Receptor for advanced glycation end products RUNX2: Runt-related transcription factor 2 s-GAG: sulfated glycosaminoglycans SAT: Subcutaneous adipose tissue SDF-1: Stromal cell-derived factor 1 SIRT1: Sirtuin 1 SOX2: SRY-box transcription factor 2 SPC: Surfactant protein C sPLA2: Secretory phospholipase A SREBP1: Sterol regulatory element-binding protein 1 SVF: Stromal vascular fraction T2D: type 2 diabetes TNF- : Tumor necrosis factor alpha TSG-6: Tumor necrosis factor-stimulated gene 6 UCP1: Uncoupling protein 1 VAT: Visceral adipose tissue VDAC3: Voltage-dependent Anion Channel 3 Wnt: Wingless/Integrated signaling pathway WNT3A: Wnt family member 3 A MEM: -Minimum Essential Medium References Holst, J
However, the weight loss benefit observed in diabetes patients suggested a broader application beyond glucose management
It lowers blood glucose and increases insulin sensitivity, thereby reducing insulin resistance
Cell Stem Cell 24 , 974982 e973 (2019)
