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One is that it issues investigational status (IND) for new drugs in clinical trials this is managed by member states in the EU

Steullet P, Neijt HC, Cunod M, Do KQ (2006)

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Evidence-Base Disclosure The published evidence base for IGF-1 LR3 consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

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