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Ethics declarations Conflict of interest Exendin-4-Fc has been developed as a drug (under name JY09) for type 2 diabetes and a Phase II clinical trial (#CTR20192166) is being carried out in China

In animal models, GLP-1R agonists prevent capillary rarefaction and microvascular barrier dysfunction and reduce apoptosis and reactive oxygen species in microvascular endothelial cells, contributing to improved organ function and reduced progression of microvascular complications [162]

The semaglutide shortage was declared resolved, and the legal basis for mass compounding largely disappeared

So that patient counseling part I think is so important

This is speculative

For dosing, the statement recommends starting at the lowest possible dose and increasing slowly