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While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation
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Furthermore, both the canonical and non-canonical signaling pathways require the dimerization and autophosphorylation of c-Met
Feb 2010;7(2):80-7
Pre-existing conditions can change the risk-benefit calculation
The right choice, however, comes down to one critical factor: absorption
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