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The shift to self-administration GLP-1 therapies are changing patient expectations for injectable treatments

Nonetheless, it is also clear that intra-islet GLP-1R signaling is essential for GSIS, with more evidence that an intra-islet paracrine GLP-1 signaling is physiologically present (212, 213) and necessary for -cell health under metabolic (214)

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Clinical experience and limited human data suggest daily doses between 200-1000 g, with 500 g representing a commonly reported effective dose, though these figures lack rigorous clinical trial validation

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