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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

10.1002/humu.21607 Hum

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ROS generated from NADP (H) oxidase is critical for VEGF signaling in vitro and angiogenesis in vivo [98]