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First, the per-dose amount stays at the documented 100 mcg the way the protocol scales is by adding pulses, not by inflating a single injection

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This is important for patients with prior heart events

Additional preclinical work would be quite valuable to address this, added Rinaman

The growth-promoting effects of growth hormone include muscle tissue hypertrophy (which may be desired by some but represents an anabolic effect), bone growth and remodeling (problematic after growth plates close), organ enlargement with chronic supraphysiologic doses (cardiac hypertrophy, acromegaly features), connective tissue proliferation (potentially contributing to joint pain and carpal tunnel syndrome), and cellular proliferation that may support tumor growth in susceptible individuals