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Gclc f/f mice were generated as described 30 and crossed with the Rosa26-CreERT2 mouse strain (Jackson Labs, #008463) or Nrf2 f/f mouse strain (Jackson Labs, #025433)
2f, g), which are known inducers of PI3K/AKT 67,68 and suppressors of PTEN 69
[PubMed] Kannengiesser K, Maaser C, Heidemann J, et al
In the foundational characterization work by Raun and colleagues, Ipamorelin was described as the first GHRP to release growth hormone with a potency and specificity comparable to GHRP-6 but without the accompanying cortisol and prolactin rise
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1) Patients with hypersensitivity reaction to thioctic acid (a-lipoic acid) and components of this drug 2) Children and adolescents (less clinical experience) 3
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