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Moreover, EEC have recently been identified as producers of IL-17C in IBD, a novel member of the IL-17 cytokine family, and most likely involved in the pathogenesis of active IBD (156)
However, when the level of long-chain acylcarnitines (LCACs) is abnormally elevated, not only is it a signal of mitochondrial dysfunction but its high concentration can also aggravate mitochondrial damage and further deteriorate mitochondrial function [20, 21]
Similar beneficial effects of GLP-1/Gcg coagonism on energy and glucose metabolism have been demonstrated in humans
This inactivation disrupts key enzymatic reactions, including the conversion of methylmalonyl-CoA to succinyl-CoA by methylmalonyl-CoA mutase and the synthesis of methionine from homocysteine (Hcy) by methionine synthase (Figure 2)
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