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In terms of protein expression, immunolocalization of GPx1 revealed reduced lamina propria expression in biopsies from patients with CD compared to control, that was more marked in biopsies from areas of active inflammation (Fig
PMCID: PMC4823251
When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention
Valassina et al., 2022)
Additionally, emerging evidence suggests oral GLP-1 medications can be effective for weight maintenance, offering patients a practical option for sustaining progress
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