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Cancer Discov 2013
A notable proportion of patients with NAFLD progress to non-alcoholic steatohepatitis (NASH), a more severe form characterized by hepatic inflammation and varying degrees of fibrosis
In the present study, d-carnitine not only stimulated the expression of genes involved in glycolysis and reduced the expression of genes involved in gluconeogenesis, but also reduced liver glycogen stores and enhanced the production of lactic acid and d-citramalic acid from pyruvate, as demonstrated by the metabolomics data
They also tend to decrease appetite and slow digestion
Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body
doi:10.1038/nature05291
