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The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE, compared to 17% to 43% with placebo

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Subsequent studies demonstrated that the -subunit of the F 1 F 0 -ATP synthase complex can actually be found in the plasma membranes of hepatocytes associated with ATP hydrolase activity at the cell surface

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