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The effects of delayed gastric emptying may further compound the risk factors harbored by the obese, diabetic patient: Gastroparesis secondary to diabetes-related autonomic dysfunction Bowel dysmotility from opioids (chronic pain) and prolonged bed-rest Altered oesophageal-gastric anatomy from bariatric surgery Gastric insufflation from overzealous bag-valve ventilation with high PEEP and difficult airway Reduced efficacy of routine antiemetic regime Nausea and vomiting are reported by approximately 50% of patients using GLP-1 agonists, as direct results of reduced gastric motility and activation of central satiety centers
Type 2 diabetes in adults: management (NG28) NICE
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Blood was collected via a jugular vein catheter at 5, 15 and 30 min and 1, 2, 4, 8 and 24 h after intravenous dosing, or for intraduodenal groups at 15 min predose and 0.5, 1, 2, 4, 8, 24 and 48 h postdose
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Cancer Drug Targets 5 , 4349 (2005)
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