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[16] [2] Conditions such as hypothyroidism, polycystic ovary syndrome (PCOS), or previous metabolic surgery may alter treatment response
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Currently, the most prominent research gaps and future perspectives to fully translate these metabolic insights into clinical breakthroughs are: Understanding the Interplay Between Metabolism, Epigenetics, and Transcription: A deeper elucidation of the precise molecular mechanisms by which metabolic modulations influence CAR T cell fate, particularly their intricate interplay with epigenetic modifications (e.g., the role of acetyl-CoA in histone acetylation), is paramount
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