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This is a well-characterized pathway with decades of mechanistic research behind it

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[32] Drug interactions [edit] Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together

S1A), after which the concentrations of 2 nM and 10 nM were selected for further experiments based on the severity of the phenotypes, including 0.1% DMSO as a solvent control