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Additionally, topiroxostat inhibits the ATP-binding cassette transporter G2 (ABCG2), which plays a key role in renal uric acid reabsorption and the secretion of uric acid from the intestines

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Notably, 5OP (pKa = 1.76) is a stronger acid than l-proline (pKa = 1.99)

Over 250 pounds (113kg+): Maximum standard dosing of 500mcg applies, though some individuals may benefit from extending cycle length rather than increasing dose

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