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Rybelsus (oral semaglutide), for example, requires taking it on an empty stomach with no more than 4 ounces of water, then waiting at least 30 minutes before eating, drinking, or taking other medications

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The peptide is primarily degraded through proteolysis rather than renal excretion, so kidney function is less critical than with some other drugs

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Notably, ablation of vagal inputs, whether by surgical or chemical methods, has been shown to block the appetite-suppressing effects of peripheral GLP-1 in rodent models (Kanoski et al., 2011