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The dose toxic to the liver is quite variable from person to person and is often thought to be lower in chronic alcoholics

In: Dodda JM, Deshmukh K, Bezuidenhout D, editors

This can include increased wheezing, shortness of breath, and chest tightness

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Detoxication reactions of glutathione and glutathione transferases [PMID: 3541402] Laboratory literature summary: Detoxication reactions of glutathione and glutathione transferases

Hence, FOXO-DRI protein or other modified alternatives may be valuable in researching certain neurodegenerative conditions by substituting the absence of native FOXO proteins